TEMSYL TABLETS

Composition

Each Tab contains : Ethamsylate 250 mg , Tranexamic Acid 250 mg

Indications

 

Obstetrics & Gynecological surgery

Oral / orthopaedic / ocular surgery

Menorrhagia / metrorrhagia

IUCD (Intra Uterine Contraceptive Device) insertion

Pharmacodynamics of Tranexamic Acid

 

Tranexamic acid is a synthetic derivative of the amino acid lysine. It exerts its antifibrinolytic effect through the reversible blockade of lysine binding sites on plasminogen molecules. It inhibits endometrial plasminogen activator and thus prevents fibrinolysis and the breakdown of clot.

Pharmacodynamics of Etamsylate

 

Increases availability of Hyaluronic acid and thereby maintains capillary resistance.

Inhibits synthesis of prostacycline synthetase and thereby favours platelet aggregation.

Improves availability of platelet factors and enhances platelet function.

Contraindication

 

1. Hypersensitivity

2. Lysis of existing extra vascular clot may be inhibited in patients receiving Tranexamic acid, and Drug with action of haemostatic should be given with caution to patients on anti-fibrinolytic therapy. The potential for thrombus formation may be increased by estrogen.

Dosage

 

1-2 Tab. three times in a day, as per doctor's recommendation